Message Board

	Meetings, activities & publications
APRIL 2007 Scientific papers Rink L, Slupianek A, Stoklosa T, Nieborowska-Skorska M, Urbanska K, Seferynska I, Reiss K, Skorski T. Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex RAD50-Mre11-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells. Blood. 2007 Apr 12; [Epub ahead of print]
Cahill D, Carney JP. Dimerization of the Rad50 protein is independent of the conserved hook domain. Mutagenesis. 2007 Apr 9; [Epub ahead of print]
MARCH 2007 Scientific papers Sakamoto S, Iijima K, Mochizuki D, Nakamura K, Teshigawara K, Kobayashi J, Matsuura S, Tauchi H, Komatsu K. Homologous recombination repair is regulated by domains at the N- and C-terminus of NBS1 and is dissociated with ATM functions. Oncogene. 2007 Mar 26; [Epub ahead of print]
de Feraudy S, Limoli CL, Giedzinski E, Karentz D, Marti TM, Feeney L, Cleaver JE. Pol eta is required for DNA replication during nucleotide deprivation by hydroxyurea. Oncogene. 2007 Mar 19; [Epub ahead of print]
Soderlund K, Stal O, Skoog L, Rutqvist LE, Nordenskjold B, Askmalm MS. Intact mre11/rad50/nbs1 complex predicts good response to radiotherapy in early breast cancer. Int J Radiat Oncol Biol Phys. 2007 May 1;68(1):50-8. Epub 2007 Mar 6.
Subba Rao K. Mechanisms of disease: DNA repair defects and neurological disease. Nat Clin Pract Neurol. 2007 Mar;3(3):162-72. Review.
FEBRUARY 2007 Scientific papers Sokolenko AP, Rozanov ME, Mitiushkina NV, Sherina NY, Iyevleva AG, Chekmariova EV, Buslov KG, Shilov ES, Togo AV, Bit-Sava EM, Voskresenskiy DA, Chagunava OL, Devilee P, Cornelisse C, Semiglazov VF, Imyanitov EN. Founder mutations in early-onset, familial and bilateral breast cancer patients from Russia. Fam Cancer. 2007 Feb 28; [Epub ahead of print]
Jakubowska A, Cybulski C, Szymanska A, Huzarski T, Byrski T, Gronwald J, Debniak T, Gorski B, Kowalska E, Narod SA, Lubinski J. BARD1 and breast cancer in Poland. Breast Cancer Res Treat. 2007 Feb 27; [Epub ahead of print]
Compton SA, Choi JH, Cesare AJ, Ozgur S, Griffith JD. Xrcc3 and Nbs1 are required for the production of extrachromosomal telomeric circles in human alternative lengthening of telomere cells. Cancer Res. 2007 Feb 15;67(4):1513-9.
Jiang WQ, Zhong ZH, Henson JD, Reddel RR. Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference. Oncogene. 2007 Feb 5; [Epub ahead of print]
Walsh T, King MC. Ten genes for inherited breast cancer. Cancer Cell. 2007 Feb;11(2):103-5.
Perez A, Grabenbauer GG, Sprung CN, Sauer R, Distel LV. Potential for the G2/M Arrest Assay to Predict Patient Susceptibility to Severe Reactions Following Radiotherapy. Strahlenther Onkol. 2007 Feb;183(2):99-106.
JANUARY 2007 Scientific papers Wang HW, Lin CP, Chiu JH, Chow KC, Kuo KT, Lin CS, Wang LS. Reversal of inflammation-associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin. Int J Cancer. 2007 May 1;120(9):2019-27.
Sagan D, Mortl S, Muller I, Eckardt-Schupp F, Eichholtz-Wirth H. Enhanced CD95-mediated apoptosis contributes to radiation hypersensitivity of NBS lymphoblasts. Apoptosis. 2007 Apr;12(4):753-67.
Rhee JG, Li D, Suntharalingam M, Guo C, O'Malley BW Jr, Carney JP. Radiosensitization of head/neck squamous cell carcinoma by adenovirus-mediated expression of the Nbs1 protein. Int J Radiat Oncol Biol Phys. 2007 Jan 1;67(1):273-8.
DECEMBER 2006 Scientific papers Rollinson S, Kesby H, Morgan GJ. Haplotypic variation in MRE11, RAD50 and NBS1 and risk of non-Hodgkin's lymphoma. Leuk Lymphoma. 2006 Dec;47(12):2567-83.
Luo MH, Rosenke K, Czornak K, Fortunato EA. Human cytomegalovirus disrupts both ataxia telangiectasia mutated protein (ATM)- and ATM-Rad3-related kinase-mediated DNA damage responses during lytic infection. J Virol. 2007 Feb;81(4):1934-50. Epub 2006 Dec 6.
Shin SH, Yoon MJ, Kim M, Kim JI, Lee SJ, Lee YS, Bae S. Enhanced lung cancer cell killing by the combination of selenium and ionizing radiation. Oncol Rep. 2007 Jan;17(1):209-16.
NOVEMBER 2006 Scientific papers Jiang H, Alonso MM, Gomez-Manzano C, Piao Y, Fueyo J. Oncolytic viruses and DNA-repair machinery: overcoming chemoresistance of gliomas. Expert Rev Anticancer Ther. 2006 Nov;6(11):1585-92. Review.
Stiff T, Walker SA, Cerosaletti K, Goodarzi AA, Petermann E, Concannon P, O'Driscoll M, Jeggo PA. ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J. 2006 Dec 13;25(24):5775-82. Epub 2006 Nov 23.
Mirzoeva OK, Kawaguchi T, Pieper RO. The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity. Mol Cancer Ther. 2006 Nov;5(11):2757-66.
Distel LV, Neubauer S, Keller U, Sprung CN, Sauer R, Grabenbauer GG. Individual differences in chromosomal aberrations after in vitro irradiation of cells from healthy individuals, cancer and cancer susceptibility syndrome patients. Radiother Oncol. 2006 Dec;81(3):257-63. Epub 2006 Nov 20.
Varon R, Muer A, Wagner K, Zierler H, Sodia S, Rauter L, Petek E, Tonnies H, Neitzel H, Sperling K, Kroisel PM. Nijmegen breakage syndrome (NBS) due to maternal isodisomy of chromosome 8. Am J Med Genet A. 2007 Jan 1;143(1):92-4.
Woo JL, Berk AJ. Adenovirus ubiquitin-protein ligase stimulates viral late mRNA nuclear export. J Virol. 2007 Jan;81(2):575-87. Epub 2006 Nov 1.
Laczmanska I, Gil J, Karpinski P, Stembalska A, Kozlowska J, Busza H, Trusewicz A, Pesz K, Ramsey D, Schlade-Bartusiak K, Blin N, Sasiadek MM. Influence of polymorphisms in xenobiotic-metabolizing genes and DNA-repair genes on diepoxybutane-induced SCE frequency. Environ Mol Mutagen. 2006 Dec;47(9):666-73.
Kilic SS. Case 1: A small girl with a bird-like face. Acta Paediatr. 2006 Nov;95(11):1505-8.
OCTOBER 2006 Scientific papers Ryk C, Kumar R, Thirumaran RK, Hou SM. Polymorphisms in the DNA repair genes XRCC1, APEX1, XRCC3 and NBS1, and the risk for lung cancer in never- and ever-smokers. Lung Cancer. 2006 Dec;54(3):285-92. Epub 2006 Oct 10.
Dellaire G, Ching RW, Ahmed K, Jalali F, Tse KC, Bristow RG, Bazett-Jones DP. Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR. J Cell Biol. 2006 Oct 9;175(1):55-66.
Frappart PO, McKinnon PJ. Ataxia-telangiectasia and related diseases. Neuromolecular Med. 2006;8(4):495-512.
Someya M, Sakata K, Tauchi H, Matsumoto Y, Nakamura A, Komatsu K, Hareyama M. Association of ionizing radiation-induced foci of NBS1 with chromosomal instability and breast cancer susceptibility. Radiat Res. 2006 Oct;166(4):575-82.
Steffen J, Maneva G, Poplawska L, Varon R, Mioduszewska O, Sperling K. Increased risk of gastrointestinal lymphoma in carriers of the 657del5 NBS1 gene mutation. Int J Cancer. 2006 Dec 15;119(12):2970-3.
SEPTEMBER 2006 Scientific papers Dote H, Burgan WE, Camphausen K, Tofilon PJ. Inhibition of hsp90 compromises the DNA damage response to radiation. Cancer Res. 2006 Sep 15;66(18):9211-20.
Ohnishi K, Scuric Z, Schiestl RH, Okamoto N, Takahashi A, Ohnishi T. siRNA targeting NBS1 or XIAP increases radiation sensitivity of human cancer cells independent of TP53 status. Radiat Res. 2006 Sep;166(3):454-62.
AUGUST 2006 Scientific papers Buscemi G, Carlessi L, Zannini L, Lisanti S, Fontanella E, Canevari S, Delia D. DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues. Mol Cell Biol. 2006 Nov;26(21):7832-45. Epub 2006 Aug 28.
Cernakova I, Kvasnicova M, Lovasova Z, Badova N, Drabek J, Bouchalova K, Trojanec R, Hajduch M. A duplication dup(4)(q28q35.2) de novo in a newborn. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):113-6.
Lee Y, McKinnon PJ. Responding to DNA double strand breaks in the nervous system. Neuroscience. 2007 Apr 14;145(4):1365-1374. Epub 2006 Aug 23.
Cale C, New H. The utility of the diepoxybutane test in Nijmegen breakage syndrome diagnosis. Pediatr Blood Cancer. 2006 Aug 23; [Epub ahead of print] No abstract available.
Serrano E, Lasa A, Perea G, Carnicer MJ, Brunet S, Aventin A, Sierra J, Nomdedeu JF. Acute myeloid leukemia subgroups identified by pathway-restricted gene expression signatures. Acta Haematol. 2006;116(2):77-89.
McCabe N, Turner NC, Lord CJ, Kluzek K, Bialkowska A, Swift S, Giavara S, O'connor MJ, Tutt AN, Zdzienicka MZ, Smith GC, Ashworth A. Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition. Cancer Res. 2006 Aug 15;66(16):8109-15.
Takemura H, Rao VA, Sordet O, Furuta T, Miao ZH, Meng L, Zhang H, Pommier Y. Defective Mre11-dependent activation of Chk2 by ataxia telangiectasia mutated in colorectal carcinoma cells in response to replication-dependent DNA double strand breaks. J Biol Chem. 2006 Oct 13;281(41):30814-23. Epub 2006 Aug 10.
Ziolkowska I, Mosor M, Nowak J. Regional distribution of heterozygous 657del5 mutation carriers of the NBS1 gene in Wielkopolska province (Poland). J Appl Genet. 2006;47(3):269-72.
JULY 2006 Scientific papers Karmakar P, Seki M, Kanamori M, Hashiguchi K, Ohtsuki M, Murata E, Inoue E, Tada S, Lan L, Yasui A, Enomoto T. BLM is an early responder to DNA double-strand breaks. Biochem Biophys Res Commun. 2006 Sep 15;348(1):62-9. Epub 2006 Jul 17.
Rai R, Dai H, Multani AS, Li K, Chin K, Gray J, Lahad JP, Liang J, Mills GB, Meric-Bernstam F, Lin SY. BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell. 2006 Aug;10(2):145-57. Epub 2006 Jul 27.
Kitagawa R, Kastan MB. The ATM-dependent DNA damage signaling pathway. Cold Spring Harb Symp Quant Biol. 2005;70:99-109. Review.
Alvarez D, Chou CJ, Latella L, Zeitlin SG, Ku S, Puri PL, Dervan PB, Gottesfeld JM. A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate. Cell Cycle. 2006 Jul;5(14):1537-48. Epub 2006 Jul 17.
Tomaszewska A, Srebniak M, Gnys A. [Chromosome instability syndromes] Pol Merkur Lekarski. 2006 May;20(119):577-81. Review. Polish.
Gallego MS, Barreiro CZ, Danielian S, Rosenweig SD. Positive diepoxybutane test in a patient with Nijmegen Breakage Syndrome. Pediatr Blood Cancer. 2006 Jul 21; [Epub ahead of print]
Kruger L, Demuth I, Neitzel H, Varon R, Sperling K, Chrzanowska KH, Seemanova E, Digweed M. Cancer incidence in Nijmegen breakage syndrome is modulated by the amount of a variant NBS protein. Carcinogenesis. 2007 Jan;28(1):107-11. Epub 2006 Jul 13.
Kobayashi M, Ono H, Mihara K, Tauchi H, Komatsu K, Shibata T, Shimizu H, Uchida K, Yamamoto K. ATM activation by a sulfhydryl-reactive inflammatory cyclopentenone prostaglandin. Genes Cells. 2006 Jul;11(7):779-89.
Ohnishi K, Scuric Z, Yau D, Schiestl RH, Okamoto N, Takahashi A, Ohnishi T. Heat-induced phosphorylation of NBS1 in human skin fibroblast cells. J Cell Biochem. 2006 Dec 15;99(6):1642-50.
Povirk LF. Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks. DNA Repair (Amst). 2006 Sep 8;5(9-10):1199-212. Epub 2006 Jul 5. Review.
JUNE 2006 Scientific papers Arnould S, Spanswick VJ, Macpherson JS, Hartley JA, Thurston DE, Jodrell DI, Guichard SM. Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling. Mol Cancer Ther. 2006 Jun;5(6):1602-9.
Mosor M, Ziolkowska I, Pernak-Schwarz M, Januszkiewicz-Lewandowska D, Nowak J. Association of the heterozygous germline I171V mutation of the NBS1 gene with childhood acute lymphoblastic leukemia. Leukemia. 2006 Aug;20(8):1454-6. Epub 2006 Jun 29.
Cheung VG, Ewens WJ. Heterozygous carriers of Nijmegen Breakage Syndrome have a distinct gene expression phenotype. Genome Res. 2006 Aug;16(8):973-9. Epub 2006 Jun 29.
Meyer S, White DJ, Will AM, Eden T, Sim A, Brown R, Strathdee G. No evidence of significant silencing of Fanconi genes FANCF and FANCB or Nijmegen breakage syndrome gene NBS1 by DNA hyper-methylation in sporadic childhood leukaemia. Br J Haematol. 2006 Jul;134(1):61-3.
Slijepcevic P. The role of DNA damage response proteins at telomeres--an "integrative" model. DNA Repair (Amst). 2006 Nov 8;5(11):1299-306. Epub 2006 Jun 23. Review.
Lee JH, Paull TT. Purification and biochemical characterization of ataxia-telangiectasia mutated and Mre11/Rad50/Nbs1. Methods Enzymol. 2006;408:529-39.
Sheen MR, Kim SW, Jung JY, Ahn JY, Rhee JG, Kwon HM, Woo SK. Mre11-Rad50-Nbs1 complex is activated by hypertonicity. Am J Physiol Renal Physiol. 2006 Nov;291(5):F1014-20. Epub 2006 Jun 20.
Shiloh Y. The ATM-mediated DNA-damage response: taking shape. Trends Biochem Sci. 2006 Jul;31(7):402-10. Epub 2006 Jun 13.
Steffen J, Nowakowska D, Niwinska A, Czapczak D, Kluska A, Piatkowska M, Wisniewska A, Paszko Z. Germline mutations 657del5 of the NBS1 gene contribute significantly to the incidence of breast cancer in Central Poland. Int J Cancer. 2006 Jul 15;119(2):472-5.
Porcedda P, Turinetto V, Lantelme E, Fontanella E, Chrzanowska K, Ragona R, De Marchi M, Delia D, Giachino C. Impaired elimination of DNA double-strand break-containing lymphocytes in ataxia telangiectasia and Nijmegen breakage syndrome. DNA Repair (Amst). 2006 Aug 13;5(8):904-13. Epub 2006 Jun 12.
Teng SC, Wu KJ, Tseng SF, Wong CW, Kao L. Importin KPNA2, NBS1, DNA repair and tumorigenesis. J Mol Histol. 2006 Sep;37(5-7):293-9. Epub 2006 Jun 3. Review.
MAY 2006 Scientific papers Shen M, Lan Q, Zhang L, Chanock S, Li G, Vermeulen R, Rappaport SM, Guo W, Hayes RB, Linet M, Yin S, Yeager M, Welch R, Forrest MS, Rothman N, Smith MT. Polymorphisms in genes involved in DNA double-strand break repair pathway and susceptibility to benzene-induced hematotoxicity. Carcinogenesis. 2006 Oct;27(10):2083-9. Epub 2006 May 25.
Lu J, Wei Q, Bondy ML, Li D, Brewster A, Shete S, Yu TK, Sahin A, Meric-Bernstam F, Hunt KK, Singletary SE, Ross MI, Wang LE. Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <or=55 years. Carcinogenesis. 2006 Nov;27(11):2209-16. Epub 2006 May 19.
Popanda O, Tan XL, Ambrosone CB, Kropp S, Helmbold I, von Fournier D, Haase W, Sautter-Bihl ML, Wenz F, Schmezer P, Chang-Claude J. Genetic polymorphisms in the DNA double-strand break repair genes XRCC3, XRCC2, and NBS1 are not associated with acute side effects of radiotherapy in breast cancer patients. Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):1048-50.
Hebbring SJ, Fredriksson H, White KA, Maier C, Ewing C, McDonnell SK,Jacobsen SJ, Cerhan J, Schaid DJ, Ikonen T, Autio V, Tammela TL, Herkommer K, Paiss T, Vogel W, Gielzak M, Sauvageot J, Schleutker J, Cooney KA, Isaacs W, Thibodeau SN. Role of the Nijmegen breakage syndrome 1 gene in familial and sporadic prostate cancer. Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):935-8.
Kluzek K, Zdzienicka MZ. [Complex role of the FA proteins in providing genome stability] Postepy Biochem. 2005;51(4):387-94. Polish.
Jaspers NG, Zdzienicka MZ. Inhibition of DNA synthesis by ionizing radiation: a marker for an S-phase checkpoint. Methods Mol Biol. 2006;314:51-9.
Seemanova E, Hoch J, Herzogova J, Kawaciuk I, Janda J, Kohoutova M, Seeman P, Varon R, Sperling K. [Mutations in tumor suppressor gene NBS1 in adult patients with malignancies] Cas Lek Cesk. 2006;145(3):201-3. Czech.
Park I, Avraham HK. Cell cycle-dependent DNA damage signaling induced by ICRF-193 involves ATM, ATR, CHK2, and BRCA1. Exp Cell Res. 2006 Apr 19; [Epub ahead of print]
Lee JH, Lim DS. Dual role of Nbs1 in the ataxia telangiectasia mutated-dependent DNA damage response. FEBS J. 2006 Apr;273(8):1630-6.
Dupre A, Boyer-Chatenet L, Gautier J. Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nat Struct Mol Biol. 2006 Apr 23; [Epub ahead of print]
Stockklausner C, Behnisch W, Mechtersheimer G, Moller P, Kulozik AE. Long-term remission of children with relapsed and secondary anaplastic large cell non-Hodgkin lymphoma (ALCL) following treatment with pulsed dexamethasone and low dose etoposide. Pediatr Blood Cancer. 2006 Apr 11; [Epub ahead of print]
APRIL 2006 International Workshop on AT and NBS - April 2006 - Nijmegen, The Netherlands
Scientific papers Allen-Brady K, Wong J, Camp NJ. PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size. BMC Bioinformatics. 2006 Apr 18;7(1):209 [Epub ahead of print]
Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol. 2006 Apr 24;173(2):195-206. Epub 2006 Apr 17.
Trenz K, Smith E, Smith S, Costanzo V. ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks. EMBO J. 2006 Apr 19;25(8):1764-74. Epub 2006 Apr 6.
MARCH 2006 Scientific papers Masi AD, Antoccia A, Spadoni E, Varon-Mateeva R, Maraschio P, Tanzarella C. Screening of nijmegen breakage syndrome 1 mutations in four unrelated families by polymerase chain reaction using sequence-specific primers. Genet Test. 2006 Spring;10(1):24-30.
Ham MF, Takakuwa T, Luo WJ, Liu A, Horii A, Aozasa K. Impairment of double-strand breaks repair and aberrant splicing of ATM and MRE11 in leukemia-lymphoma cell lines with microsatellite instability. Cancer Sci. 2006 Mar;97(3):226-34.
Zhou J, Lim CU, Li JJ, Cai L, Zhang Y. The role of NBS1 in the modulation of PIKK family proteins ATM and ATR in the cellular response to DNA damage. Cancer Lett. 2006 Mar 9; [Epub ahead of print]
Becker E, Meyer V, Madaoui H, Guerois R. Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response. Bioinformatics. 2006 Mar 7; [Epub ahead of print]
Seemanova E, Jarolim P, Seeman P, Varon R, Sperling K. [Increased risk of malignancies in heterozvgotes in families of patients with Nijmegen breakage syndrome] Cas Lek Cesk. 2006;145(2):138-43. Czech.
Cerosaletti K, Wright J, Concannon P. Active role for nibrin in the kinetics of atm activation. Mol Cell Biol. 2006 Mar;26(5):1691-9.
Chrzanowska KH, Piekutowska-Abramczuk D, Popowska E, Gladkowska-Dura M, Maldyk J, Syczewska M, Krajewska-Walasek M, Goryluk-Kozakiewicz B, Bubala H, Gadomski A, Gaworczyk A, Kazanowska B, Koltan A, Kuzmicz M, Luszawska-Kutrzeba T, Maciejka-Kapuscinska L, Stolarska M, Stefanska K, Sznurkowska K, Wakulinska A, Wieczorek M, Szczepanski T, Kowalczyk J. Carrier frequency of mutation 657del5 in the NBS1 gene in a population of Polish pediatric patients with sporadic lymphoid malignancies. Int J Cancer. 2006 Mar 1;118(5):1269-74.
FEBRUARY 2006 Scientific papers Burger S, Schindler D, Fehn M, Muhl B, Mahrhofer H, Flentje M, Hoehn H, Seemanova E, Djuzenova CS. Radiation-induced DNA damage and repair in peripheral blood mononuclear cells from Nijmegen breakage syndrome patients and carriers assessed by the Comet assay. Environ Mol Mutagen. 2006 Feb 8; [Epub ahead of print]
Thirumaran RK, Bermejo JL, Rudnai P, Gurzau E, Koppova K, Goessler W, Vahter M, Leonardi GS, Clemens F, Fletcher T, Hemminki K, Kumar R. Single nucleotide polymorphisms in DNA repair genes and basal cell carcinoma of skin. Carcinogenesis. 2006 Feb 25; [Epub ahead of print]
Taniguchi T, D'Andrea AD. The molecular pathogenesis of fanconi anemia: recent progress. Blood. 2006 Feb 21; [Epub ahead of print]
Ho CC, Siu WY, Lau A, Chan WM, Arooz T, Poon RY. Stalled replication induces p53 accumulation through distinct mechanisms from DNA damage checkpoint pathways. Cancer Res. 2006 Feb 15;66(4):2233-41.
Adams KE, Medhurst AL, Dart DA, Lakin ND. Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex. Oncogene. 2006 Feb 13; [Epub ahead of print]
Heikkinen K, Rapakko K, Karppinen SM, Erkko H, Knuutila S, Lundan T, Mannermaa A, Borresen-Dale AL, Borg A, Barkardottir RB, Petrini J, Winqvist R. RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability. Carcinogenesis. 2006 Feb 12; [Epub ahead of print]
Rossi R, Lidonnici MR, Soza S, Biamonti G, Montecucco A. The dispersal of replication proteins after Etoposide treatment requires the cooperation of Nbs1 with the ataxia telangiectasia Rad3-related/Chk1 pathway. Cancer Res. 2006 Feb 1;66(3):1675-83.
Chai W, Sfeir AJ, Hoshiyama H, Shay JW, Wright WE. The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. EMBO Rep. 2006 Feb;7(2):225-30.
JANUARY 2006 Scientific papers Zhang Y, Zhou J, Lim CU. The role of NBS1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control. Cell Res. 2006 Jan;16(1):45-54.
Chatterjee M, Mohapatra S, Ionan A, Bawa G, Ali-Fehmi R, Wang X, Nowak J, Ye B, Nahhas FA, Lu K, Witkin SS, Fishman D, Munkarah A, Morris R, Levin NK, Shirley NN, Tromp G, Abrams J, Draghici S, Tainsky MA. Diagnostic markers of ovarian cancer by high-throughput antigen cloning and detection on arrays. Cancer Res. 2006 Jan 15;66(2):1181-90.
Frame FM, Rogoff HA, Pickering MT, Cress WD, Kowalik TF. E2F1 induces MRN foci formation and a cell cycle checkpoint response in human fibroblasts. Oncogene. 2006 Jan 23; [Epub ahead of print]
Yang MH, Chiang WC, Chou TY, Chang SY, Chen PM, Teng SC, Wu KJ. Increased NBS1 expression is a marker of aggressive head and neck cancer and overexpression of NBS1 contributes to transformation. Clin Cancer Res. 2006 Jan 15;12(2):507-15.
Varon R, Dutrannoy V, Weikert G, Tanzarella C, Antoccia A, Stockl L, Spadoni E, Kruger LA, Masi A, Sperling K, Digweed M, Maraschio P. Mild Nijmegen breakage syndrome phenotype due to alternative splicing. Hum Mol Genet. 2006 Mar 1;15(5):679-89. Epub 2006 Jan 13.
Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature. 2006 Mar 2;440(7080):105-9. Epub 2006 Jan 8.
Tekin M, Akcayoz D, Ucar C, Gulen H, Akar N. 657del5 mutation of the Nijmegen breakage syndrome gene (NBS1) in the Turkish population. Hum Biol. 2005 Jun;77(3):393-7.
Greenberg RA, Sobhian B, Pathania S, Cantor SB, Nakatani Y, Livingston DM. Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. Genes Dev. 2006 Jan 1;20(1):34-46.
Robert F, Hardy S, Nagy Z, Baldeyron C, Murr R, Dery U, Masson JY, Papadopoulo D, Herceg Z, Tora L. The transcriptional histone acetyltransferase cofactor TRRAP associates with the MRN repair complex and plays a role in DNA double-strand break repair. Mol Cell Biol. 2006 Jan;26(2):402-12.
DECEMBER 2005 Scientific papers Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH. The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev. 2005 Dec 15;19(24):3043-54.
Cousineau I, Abaji C, Belmaaza A. BRCA1 regulates RAD51 function in response to DNA damage and suppresses spontaneous sister chromatid replication slippage: implications for sister chromatid cohesion, genome stability, and carcinogenesis. Cancer Res. 2005 Dec 15;65(24):11384-91.
Ryk C, Kumar R, Sanyal S, Verdier PJ, Hemminki K, Larsson P, Steineck G, Hou SM. Influence of polymorphism in DNA repair and defence genes on p53 mutations in bladder tumours. Cancer Lett. 2005 Dec 9; [Epub ahead of print]
Rezacova M, Vavrova J, Cerman J. [A cell and genotoxic stress: a reaction to double strand breaks of DNA] Cas Lek Cesk. 2005;144 Suppl 3:13-7. Review. Czech.
Di Virgilio M, Gautier J. Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11. J Cell Biol. 2005 Dec 5;171(5):765-71.
Jazayeri A, Falck J, Lukas C, Bartek J, Smith GC, Lukas J, Jackson SP. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol. 2006 Jan;8(1):37-45. Epub 2005 Dec 4.
Gibson SL, Bindra RS, Glazer PM. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Res. 2005 Dec 1;65(23):10734-41.
NOVEMBER 2005 Scientific papers Howlett NG, Scuric Z, D'Andrea AD, Schiestl RH. Impaired DNA double strand break repair in cells from Nijmegen breakage syndrome patients. DNA Repair (Amst). 2006 Feb 3;5(2):251-7. Epub 2005 Nov 22.
Verdun RE, Crabbe L, Haggblom C, Karlseder J. Functional human telomeres are recognized as DNA damage in G2 of the cell cycle. Mol Cell. 2005 Nov 23;20(4):551-61.
Larson ED, Cummings WJ, Bednarski DW, Maizels N. MRE11/RAD50 cleaves DNA in the AID/UNG-dependent pathway of immunoglobulin gene diversification. Mol Cell. 2005 Nov 11;20(3):367-75.
Liu Y, Shevchenko A, Shevchenko A, Berk AJ. Adenovirus exploits the cellular aggresome response to accelerate inactivation of the MRN complex. J Virol. 2005 Nov;79(22):14004-16.
OCTOBER 2005 Scientific papers Muntoni A, Reddel RR. The first molecular details of ALT in human tumor cells. Hum Mol Genet. 2005 Oct 15;14 Spec No. 2:R191-6. Review.
Marcelain K, De La Torre C, Gonzalez P, Pincheira J. Roles of nibrin and AtM/ATR kinases on the G2 checkpoint under endogenous or radio-induced DNA damage. Biol Res. 2005;38(2-3):179-85.
Lin SY, Rai R, Li K, Xu ZX, Elledge SJ. BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15105-9. Epub 2005 Oct 10.
Millikan RC, Player JS, Decotret AR, Tse CK, Keku T. Polymorphisms in DNA repair genes, medical exposure to ionizing radiation, and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2005 Oct;14(10):2326-34.
Bi X, Srikanta D, Fanti L, Pimpinelli S, Badugu R, Kellum R, Rong YS. Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15167-72. Epub 2005 Oct 3.
Collins N, Kupfer GM. Molecular pathogenesis of Fanconi anemia. Int J Hematol. 2005 Oct;82(3):176-83. Review.
SEPTEMBER 2005 Scientific papers Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland L, Phillips DH, Canzian F, Haugen A. Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. Carcinogenesis. 2006 Mar;27(3):560-7. Epub 2005 Sep 29.
Tseng SF, Chang CY, Wu KJ, Teng SC. Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1. J Biol Chem. 2005 Nov 25;280(47):39594-600. Epub 2005 Sep 27.
Araten DJ, Golde DW, Zhang RH, Thaler HT, Gargiulo L, Notaro R, Luzzatto L. A quantitative measurement of the human somatic mutation rate. Cancer Res. 2005 Sep 15;65(18):8111-7. Erratum in: Cancer Res. 2005 Nov 15;65(22):10635.
Kitsera NI, Polishchuk RS, Akopian HR, Markevych NV, Kostiuchenko LV, Troianovs'ka OO, Skoropad LL. [Clinical and genealogical characteristics in families with Nijmegen breakage syndrome] Tsitol Genet. 2005 Mar-Apr;39(2):72-8. Ukrainian.
Kook H. Fanconi anemia: current management. Hematology. 2005;10 Suppl 1:108-10.
Williams RS, Tainer JA. A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks. Mol Cell. 2005 Sep 16;19(6):724-6.
Moreno-Herrero F, de Jager M, Dekker NH, Kanaar R, Wyman C, Dekker C. Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA. Nature. 2005 Sep 15;437(7057):440-3.
Lan L, Nakajima S, Komatsu K, Nussenzweig A, Shimamoto A, Oshima J, Yasui A. Accumulation of Werner protein at DNA double-strand breaks in human cells. J Cell Sci. 2005 Sep 15;118(Pt 18):4153-62. Epub 2005 Sep 1.
Papadopoulo D, Moustacchi E. [Fanconi anemia: genes and function(s) revisited] Med Sci (Paris). 2005 Aug-Sep;21(8-9):730-6. Review. French.
Durant ST, Nickoloff JA. Good timing in the cell cycle for precise DNA repair by BRCA1. Cell Cycle. 2005 Sep;4(9):1216-22. Epub 2005 Sep 13.
Araujo FD, Stracker TH, Carson CT, Lee DV, Weitzman MD. Adenovirus type 5 E4orf3 protein targets the Mre11 complex to cytoplasmic aggresomes. J Virol. 2005 Sep;79(17):11382-91.
AUGUST 2005 Scientific papers Pommier Y, Sordet O, Rao VA, Zhang H, Kohn KW. Targeting chk2 kinase: molecular interaction maps and therapeutic rationale. Curr Pharm Des. 2005;11(22):2855-72. Review.
Allen-Brady K, Camp NJ. Characterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes. BMC Cancer. 2005 Aug 9;5:99.
Ben-Omran TI, Cerosaletti K, Concannon P, Weitzman S, Nezarati MM. A patient with mutations in DNA Ligase IV: clinical features and overlap with Nijmegen breakage syndrome. Am J Med Genet A. 2005 Sep 1;137(3):283-7.
Zhong H, Bryson A, Eckersdorff M, Ferguson DO. Rad50 depletion impacts upon ATR-dependent DNA damage responses. Hum Mol Genet. 2005 Sep 15;14(18):2685-93. Epub 2005 Aug 8.
Kim JS, Krasieva TB, Kurumizaka H, Chen DJ, Taylor AM, Yokomori K. Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells. J Cell Biol. 2005 Aug 1;170(3):341-7.
Ball LG, Xiao W Molecular basis of ataxia telangiectasia and related diseases. Acta Pharmacol Sin. 2005 Aug;26(8):897-907.
JULY 2005 Scientific papers Chen YC, Su YN, Chou PC, Chiang WC, Chang MC, Wang LS, Teng SC, Wu KJ. Overexpression of NBS1 contributes to transformation through the activation of phosphatidylinositol 3-kinase/Akt. J Biol Chem. 2005 Jul 21; [Epub ahead of print]
Seemanova E, Sperling K, Neitzel H, Varon R, Hadac J, Butova O, Schrock E, Seeman P, Digweed M. Nijmegen Breakage Syndrome (NBS) with neurological abnormalities and without chromosomal instability. J Med Genet. 2005 Jul 20; [Epub ahead of print]
Bhoumik A, Takahashi S, Breitweiser W, Shiloh Y, Jones N, Ronai Z. ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol Cell. 2005 May 27;18(5):577-87.
Koh KH, Kang HJ, Li LS, Kim NG, You KT, Yang E, Kim H, Kim HJ, Yun CO, Kim KS, Kim H. Impaired nonhomologous end-joining in mismatch repair-deficient colon carcinomas. Lab Invest. 2005 Jul 18; [Epub ahead of print]
Fagundes MR, Semighini CP, Malavazi I, Savoldi M, de Lima JF, de Souza Goldman MH, Harris SD, Goldman GH. Aspergillus nidulans uvsBATR and scaANBS1 genes show genetic interactions during recovery from replication stress and DNA damage. Eukaryot Cell. 2005 Jul;4(7):1239-52.
Eyfjord JE, Bodvarsdottir SK. Genomic instability and cancer: Networks involved in response to DNA damage. Mutat Res. 2005 Jul 4; [Epub ahead of print]
Zhang L, Zhang Z, Yan W. Single nucleotide polymorphisms for DNA repair genes in breast cancer patients. Clin Chim Acta. 2005 Jul 5; [Epub ahead of print]
Zhang Y, Lim CU, Williams ES, Zhou J, Zhang Q, Fox MH, Bailey SM, Liber HL. NBS1 knockdown by small interfering RNA increases ionizing radiation mutagenesis and telomere association in human cells. Cancer Res. 2005 Jul 1;65(13):5544-53.
Stavridi ES, Halazonetis TD. Nbs1 moving up in the world. Nat Cell Biol. 2005 Jul;7(7):648-50.
Lefevre SH, Coquelle A, Gonin-Laurent N, Cor A, Vogt N, Chauveinc L, Anract P, Dutrillaux B, Chevillard S, Malfoy B. Non-homologous end-joining genes are not inactivated in human radiation-induced sarcomas with genomic instability. J Radiat Res (Tokyo). 2005 Jun;46(2):223-31.
Gorski B, Cybulski C, Huzarski T, Byrski T, Gronwald J, Jakubowska A, Stawicka M, Gozdecka-Grodecka S, Szwiec M, Urbanski K, Mitus J, Marczyk E, Dziuba J, Wandzel P, Surdyka D, Haus O, Janiszewska H, Debniak T, Toloczko-Grabarek A, Medrek K, Masojc B, Mierzejewski M, Kowalska E, Narod SA, Lubinski J. Breast cancer predisposing alleles in Poland. Breast Cancer Res Treat. 2005 Jul;92(1):19-24.
Boisvert FM, Hendzel MJ, Masson JY, Richard S. Methylation of MRE11 Regulates its Nuclear Compartmentalization. Cell Cycle. 2005 Jul 9;4(7) [Epub ahead of print]
Andrews CA, Clarke DJ. MRX (Mre11/Rad50/Xrs2) Mutants Reveal Dual Intra-S-Phase Checkpoint Systems in Budding Yeast. Cell Cycle. 2005 Aug 19;4(8) [Epub ahead of print]
Cabuy E, Newton C, Joksic G, Woodbine L, Koller B, Jeggo PA, Slijepcevic P. Accelerated telomere shortening and telomere abnormalities in radiosensitive cell lines. Radiat Res. 2005 Jul;164(1):53-62.
Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F, Yang YP, Petukhova GV, Eckhaus M, Feigenbaum L, Manova K, Kruhlak M, Camerini-Otero RD, Sharan S, Nussenzweig M, Nussenzweig A. Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models. Nat Cell Biol. 2005 Jul;7(7):675-85. Epub 2005 Jun 19.
Shirata N, Kudoh A, Daikoku T, Tatsumi Y, Fujita M, Kiyono T, Sugaya Y, Isomura H, Ishizaki K, Tsurumi T. Activation of ATM DNA damage checkpoint signal transduction elicited by Herpes simplex virus infection. J Biol Chem. 2005 Jun 17; [Epub ahead of print]
Chiolo I, Carotenuto W, Maffioletti G, Petrini JH, Foiani M, Liberi G. Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Mol Cell Biol. 2005 Jul;25(13):5738-51.
You Z, Chahwan C, Bailis J, Hunter T, Russell P. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol. 2005 Jul;25(13):5363-79.
Malavazi I, Lima JF, von Zeska Kress Fagundes MR, Efimov VP, de Souza Goldman MH, Goldman GH. The Aspergillus nidulans sldI(RAD50) gene interacts with bimE(APC1), a homologue of an anaphase-promoting complex subunit. Mol Microbiol. 2005 Jul;57(1):222-37.
Yabuki M, Fujii MM, Maizels N. The MRE11-RAD50-NBS1 complex accelerates somatic hypermutation and gene conversion of immunoglobulin variable regions. Nat Immunol. 2005 Jul;6(7):730-6. Epub 2005 Jun 5.
JUNE 2005
JUNE 2005 Scientific papers Abraham RT, Tibbetts RS. Cell biology. Guiding ATM to broken DNA. Science. 2005 Apr 22;308(5721):510-1.
Auranen A, Song H, Waterfall C, Dicioccio RA, Kuschel B, Kjaer SK, Hogdall E, Hogdall C, Stratton J, Whittemore AS, Easton DF, Ponder BA, Novik KL, Dunning AM, Gayther S, Pharoah PD. Polymorphisms in DNA repair genes and epithelial ovarian cancer risk. Int J Cancer. 2005 May 27; [Epub ahead of print]
Lan Q, Shen M, Berndt SI, Bonner MR, He X, Yeager M, Welch R, Keohavong P, Donahue M, Hainaut P, Chanock S. Smoky coal exposure, NBS1 polymorphisms, p53 protein accumulation, and lung cancer risk in Xuan Wei, China. Lung Cancer. 2005 May 24; [Epub ahead of print]
Festa F, Kumar R, Sanyal S, Unden B, Nordfors L, Lindholm B, Snellman E, Schalling M, Forsti A, Hemminki K. Basal cell carcinoma and variants in genes coding for immune response, DNA repair, folate and iron metabolism. Mutat Res. 2005 Jul 1;574(1-2):105-11. Epub 2005 Mar 26.
Paull TT, Lee JH. The Mre11/Rad50/Nbs1 Complex and Its Role as a DNA Double-Strand Break Sensor for ATM. Cell Cycle. 2005 Jun 6;4(6) [Epub ahead of print]
Hsu HL, Shi B, Gartenhaus RB. The MCT-1 oncogene product impairs cell cycle checkpoint control and transforms human mammary epithelial cells. Oncogene. 2005 May 9; [Epub ahead of print]
Stracker TH, Lee DV, Carson CT, Araujo FD, Ornelles DA, Weitzman MD. Serotype-specific reorganization of the Mre11 complex by adenoviral E4orf3 proteins. J Virol. 2005 Jun;79(11):6664-73.
Bonatti S, Simili M, Benedetti PA, Morandi F, Menichini P, Carratore RD, Barale R, Abbondandolo A. Altered centrosomes in ataxia-telangiectasia cells and rapamycin-treated Chinese hamster cells. Environ Mol Mutagen. 2005 May 26; [Epub ahead of print]
Wistop A, Keller U, Sprung CN, Grabenbauer GG, Sauer1 R, Distel LV. Individual Radiosensitivity Does not Correlate with Radiation-Induced Apoptosis in Lymphoblastoid Cell Lines or CD3+ Lymphocytes. Strahlenther Onkol. 2005 May;181(5):326-335.
MAY 2005 Scientific papers Pan J, She M, Xu ZX, Sun L, Yeung SC. Farnesyltransferase inhibitors induce DNA damage via reactive oxygen species in human cancer cells. Cancer Res. 2005 May 1;65(9):3671-81.
Evans JD, Hearing P. Relocalization of the Mre11-Rad50-Nbs1 Complex by the Adenovirus E4 ORF3 Protein Is Required for Viral Replication. J Virol. 2005 May;79(10):6207-15.
French D, Wilkinson MR, Yang W, de Chaisemartin L, Cook EH, Das S, Ratain MJ, Evans WE, Downing JR, Pui CH, Relling MV. Global Gene Expression as a Function of Germline Genetic Variation. Hum Mol Genet. 2005 Apr 27; [Epub ahead of print]
Kim ST. Protein kinase CK2 interacts with Chk2 and phosphorylates Mre11 on serine 649. Biochem Biophys Res Commun. 2005 May 27;331(1):247-52.
Slijepcevic P, Al-Wahiby S. Telomere biology: integrating chromosomal end protection with DNA damage response. Chromosoma. 2005 Apr 21; [Epub ahead of print]
APRIL 2005 Scientific papers Frappart PO, Tong WM, Demuth I, Radovanovic I, Herceg Z, Aguzzi A, Digweed M, Wang ZQ. An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat Med. 2005 Apr 10; [Epub ahead of print]
Smith S, Gupta A, Kolodner RD, Myung K. Suppression of gross chromosomal rearrangements by the multiple functions of the Mre11-Rad50-Xrs2 complex in Saccharomyces cerevisiae. DNA Repair (Amst). 2005 May 2;4(5):606-17.
Warters RL, Adamson PJ, Pond CD, Leachman SA. Melanoma Cells Express Elevated Levels of Phosphorylated Histone H2AX Foci. J Invest Dermatol. 2005 Apr;124(4):807-17.
MARCH 2005 Scientific papers Lee JH, Paull TT. ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex. Science. 2005 Mar 24; [Epub ahead of print]
Townsend PA, Cragg MS, Davidson SM, McCormick J, Barry S, Lawrence KM, Knight RA, Hubank M, Chen PL, Latchman DS, Stephanou A. STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage. J Cell Sci. 2005 Mar 22; [Epub ahead of print]
Dumitrescu RG, Cotarla I. Understanding breast cancer risk - where do we stand in 2005? J Cell Mol Med. 2005 Jan-Mar;9(1):208-21.
Jiang WQ, Zhong ZH, Henson JD, Neumann AA, Chang AC, Reddel RR. Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex. Mol Cell Biol. 2005 Apr;25(7):2708-21.
Falck J, Coates J, Jackson SP. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature. 2005 Mar 2; [Epub ahead of print]
Ehlers JP, Harbour JW. NBS1 Expression as a Prognostic Marker in Uveal Melanoma. Clin Cancer Res. 2005 Mar 1;11(5):1849-53.
Broberg K, Bjork J, Paulsson K, Hoglund M, Albin M. Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. Carcinogenesis. 2005 Mar 3; [Epub ahead of print]
Boisvert FM, Dery U, Masson JY, Richard S. Arginine methylation of MRE11 by PRMT1 is required for DNA damage checkpoint control. Genes Dev. 2005 Mar 1; [Epub ahead of print]
Alt JR, Bouska A, Fernandez MR, Cerny RL, Xiao H, Eischen CM. MDM2 binds to NBS1 at sites of DNA damage and regulates double-strand break repair. J Biol Chem. 2005 Feb 25; [Epub ahead of print]
Cheng WH, Sakamoto S, Fox JT, Komatsu K, Carney J, Bohr VA. Werner syndrome protein associates with gammaH2AX in a manner that depends upon Nbs1. FEBS Lett. 2005 Feb 28;579(6):1350-6. Epub 2005 Jan 28.
Chen L, Morio T, Minegishi Y, Nakada S, Nagasawa M, Komatsu K, Chessa L, Villa A, Lecis D, Delia D, Mizutani S. Ataxia-telangiectasia-mutated dependent phosphorylation of Artemis in response to DNA damage. Cancer Sci. 2005 Feb;96(2):134-41.
FEBRUARY 2005 Scientific papers Jeggo PA, Lobrich M. Artemis Links ATM to Double Strand Break Rejoining. Cell Cycle. 2005 Mar 6;4(3) [Epub ahead of print]
Stanislawska-Sachadyn A, Paszko Z, Kluska A, Skasko E, Sromek M, Balabas A, Janiec-Jankowska A, Wisniewska A, Kur J, Sachadyn P. Preliminary studies on DNA retardation by MutS applied to the detection of point mutations in clinical samples. Mutat Res. 2005 Feb 15;570(1):97-103.
Reina-San-Martin B, Nussenzweig MC, Nussenzweig A, Difilippantonio S. Genomic instability, endoreduplication, and diminished Ig class-switch recombination in B cells lacking Nbs1. Proc Natl Acad Sci U S A. 2005 Jan 24; [Epub ahead of print]
Kracker S, Bergmann Y, Demuth I, Frappart PO, Hildebrand G, Christine R, Wang ZQ, Sperling K, Digweed M, Radbruch A. Nibrin functions in Ig class-switch recombination. Proc Natl Acad Sci U S A. 2005 Jan 24; [Epub ahead of print]
Bradshaw PS, Stavropoulos DJ, Meyn MS. Human telomeric protein TRF2 associates with genomic double-strand breaks as an early response to DNA damage. Nat Genet. 2005 Feb;37(2):193-197. Epub 2005 Jan 23.
JANUARY 2005 Scientific papers Farah JA, Cromie G, Steiner WW, Smith GR. A novel recombination pathway initiated by the MRN complex eliminates palindromes during meiosis in Schizosaccharomyces pombe. Genetics. 2005 Jan 16; [Epub ahead of print]
Robison JG, Lu L, Dixon K, Bissler JJ. DNA lesion-specific co-localization of the MRE11/RAD50/NBS1 (MRN) complex and replication protein A (RPA) to repair foci. J Biol Chem. 2005 Jan 14; [Epub ahead of print]
Kobayashi J. Molecular Mechanism of the Recruitment of NBS1/hMRE11/hRAD50 Complex to DNA Double-strand Breaks: NBS1 Binds to gamma-H2AX through FHA/BRCT Domain. J Radiat Res (Tokyo). 2004 Dec;45(4):473-8.
Kang J, Ferguson D, Song H, Bassing C, Eckersdorff M, Alt FW, Xu Y. Functional interaction of H2AX, NBS1, and p53 in ATM-dependent DNA damage responses and tumor suppression. Mol Cell Biol. 2005 Jan;25(2):661-70.
Stiff T, Reis C, Alderton GK, Woodbine L, O'driscoll M, Jeggo PA. Nbs1 is required for ATR-dependent phosphorylation events. EMBO J. 2004 Dec 16; [Epub ahead of print]
Lee AC, Fernandez-Capetillo O, Pisupati V, Jackson SP, Nussenzweig A. Specific Association of Mouse MDC1/NFBD1 with NBS1 at Sites of DNA- Damage. Cell Cycle. 2005 Jan 11;4(1) [Epub ahead of print]
DECEMBER 2004 Scientific papers Stiff T, Reis C, Alderton GK, Woodbine L, O'driscoll M, Jeggo PA. Nbs1 is required for ATR-dependent phosphorylation events. EMBO J. 2004 Dec 16; [Epub ahead of print]
New HV, Cale CM, Tischkowitz M, Jones A, Telfer P, Veys P, D'Andrea A, Mathew CG, Hann I. Nijmegen breakage syndrome diagnosed as Fanconi anaemia. Pediatr Blood Cancer. 2004 Dec 8; [Epub ahead of print]
Buslov KG, Iyevleva AG, Chekmariova EV, Suspitsin EN, Togo AV, Kuligina ES, Sokolenko AP, Matsko DE, Turkevich EA, Lazareva YR, Chagunava OL, Bit-Sava EM, Semiglazov VF, Devilee P, Cornelisse C, Hanson KP, Imyanitov EN. NBS1 657del5 mutation may contribute only to a limited fraction of breast cancer cases in Russia. Int J Cancer. 2004 Dec 1; [Epub ahead of print]
Bekiesinska-Figatowska M, Chrzanowska KH, Jurkiewicz E, Wakulinska A, Rysiewskis H, Gladkowska-Dura M, Walecki J. Magnetic resonance imaging of brain abnormalities in patients with the Nijmegen breakage syndrome. Acta Neurobiol Exp (Wars). 2004;64(4):503-9.
Riballo E, Kuhne M, Rief N, Doherty A, Smith GC, Recio MJ, Reis C, Dahm K, Fricke A, Krempler A, Parker AR, Jackson SP, Gennery A, Jeggo PA, Lobrich M. A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. Mol Cell. 2004 Dec 3;16(5):715-24.
Angele S, Jones C, Reis Filho JS, Fulford LG, Treilleux I, Lakhani SR, Hall J. Expression of ATM, p53, and the MRE11-Rad50-NBS1 complex in myoepithelial cells from benign and malignant proliferations of the breast. J Clin Pathol. 2004 Nov;57(11):1179-84.
NOVEMBER 2004 Scientific papers Angele S, Jones C, Reis Filho JS, Fulford LG, Treilleux I, Lakhani SR, Hall J. Expression of ATM, p53, and the MRE11-Rad50-NBS1 complex in myoepithelial cells from benign and malignant proliferations of the breast. J Clin Pathol. 2004 Nov;57(11):1179-84.
Kurz EU, Douglas P, Lees-Miller SP. Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species. J Biol Chem. 2004 Oct 14 [Epub ahead of print]
Matsuura S, Kobayashi J, Tauchi H, Komatsu K. Nijmegen breakage syndrome and DNA double strand break repair by NBS1 complex. Adv Biophys. 2004;38:65-80.
Meyer S, Kingston H, Taylor AM, Byrd PJ, Last JI, Brennan BM, Trueman S, Kelsey A, Taylor GM, Eden OB. Rhabdomyosarcoma in Nijmegen breakage syndrome: strong association with perianal primary site. Cancer Genet Cytogenet. 2004 Oct 15;154(2):169-74.
Tran HM, Shi G, Li G, Carney JP, O'Malley B, Li D. Mutant Nbs1 enhances cisplatin-induced DNA damage and cytotoxicity in head and neck cancer. Otolaryngol Head Neck Surg. 2004 Oct;131(4):477-84.
Bolderson E, Scorah J, Helleday T, Smythe C, Meuth M. ATM is required for the cellular response to thymidine induced replication fork stress. Hum Mol Genet. 2004 Sep 30 [Epub ahead of print]
OCTOBER 2004 Scientific papers Gennery AR, Slatter MA, Bhattacharya A, Barge D, Haigh S, O'Driscoll M, Coleman R, Abinun M, Flood TJ, Cant AJ, Jeggo PA. The clinical and biological overlap between Nijmegen Breakage Syndrome and Fanconi anemia. Clin Immunol. 2004 Nov;113(2):214-9.
Marcelain K, Aracena M, Be C, Navarrete CL, Moreno R, Santos M, Pincheira J. [Clinical, cytogenetic and molecular characterization of a new case of Nijmegen breakage syndrome in Chile] Rev Med Chil. 2004 Feb;132(2):211-8. Spanish.
Seemanova E, Pohanka V, Seeman P, Misovicova N, Behunova J, Kvasnicova M, Dlholucky S, Valachova A, Cisarik F, Veghova E, Varon R, Sperling K. [Nijmegen breakage syndrome in Slovakia] Cas Lek Cesk. 2004;143(8):538-41; discussion 542. Czech.
SEPTEMBER 2004 Scientific papers Lavin MF. The Mre11 complex and ATM: a two-way functional interaction in recognising and signaling DNA double strand breaks. DNA Repair (Amst). 2004 Nov 2;3(11):1515-20.
Buscemi G, Perego P, Carenini N, Nakanishi M, Chessa L, Chen J, Khanna K, Delia D. Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene. 2004 Sep 13 [Epub ahead of print]
Pasic S, Vujic D, Fiorini M, Notarangelo LD. T-cell lymphoblastic leukemia/lymphoma in Nijmegen breakage syndrome. Haematologica. 2004 Aug;89(8):ECR27.
Shimada H, Shimizu K, Mimaki S, Sakiyama T, Mori T, Shimasaki N, Yokota J, Nakachi K, Ohta T, Ohki M. First case of aplastic anemia in a Japanese child with a homozygous missense mutation in the NBS1 gene (I171V) associated with genomic instability. Hum Genet. 2004 Aug 24 [Epub ahead of print]
Demuth I, Frappart PO, Hildebrand G, Melchers A, Lobitz S, Stockl L, Varon R, Herceg Z, Sperling K, Wang ZQ, Digweed M. An inducible null mutant murine model of Nijmegen Breakage Syndrome proves the essential function of NBS1 in chromosomal stability and cell viability. Hum Mol Genet. 2004 Aug 27 [Epub ahead of print]
AUGUST 2004 Scientific papers Siwicki JK, Berglund M, Rygier J, Pienkowska-Grela B, Grygalewicz B, Degerman S, Golovleva I, Chrzanowska KH, Lagercrantz S, Blennow E, Roos G, Larsson C. Spontaneously immortalized human T lymphocytes develop gain of chromosomal region 2p13-24 as an early and common genetic event. Genes Chromosomes Cancer. 2004 Oct;41(2):133-44.
Karlseder J, Hoke K, Mirzoeva OK, Bakkenist C, Kastan MB, Petrini JH, Lange Td T. The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response. PLoS Biol. 2004 Aug;2(8):E240. Epub 2004 Aug 17.
Assenmacher N, Hopfner KP. MRE11/RAD50/NBS1: complex activities. Chromosoma. 2004 Aug 10 [Epub ahead of print]
Digweed M, Sperling K. Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1207-17.
Wang X, D'Andrea AD. The interplay of Fanconi anemia proteins in the DNA damage response. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1063-9.
Kobayashi J, Antoccia A, Tauchi H, Matsuura S, Komatsu K. NBS1 and its functional role in the DNA damage response. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):855-61.
Stracker TH, Theunissen JW, Morales M, Petrini JH. The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):845-54.
Wang J, Wiltshire T, Wang Y, Mikell C, Burks J, Cunningham C, Van Laar ES, Waters SJ, Reed E, Wang W. ATM-dependent CHK2 activation induced by anticancer agent, irofulven. J Biol Chem. 2004 Jul 20 [Epub ahead of print]
Iijima K, Komatsu K, Matsuura S, Tauchi H. The Nijmegen breakage syndrome gene and its role in genome stability. Chromosoma. 2004 Sep;113(2):53-61. Epub 2004 Jul 17.
JULY 2004 Scientific papers Cerosaletti K, Concannon P. Independent roles for nibrin and Mre11/Rad50 in the activation and function of Atm. J Biol Chem. 2004 Jul 1 [Epub ahead of print]
Lane TF. BRCA1 and Transcription. Cancer Biol Ther. 2004 Jun;3(6):528-33. Epub 2004 Jun 24.
Pawlik TM, Keyomarsi K. Role of cell cycle in mediating sensitivity to radiotherapy. Int J Radiat Oncol Biol Phys. 2004 Jul 15;59(4):928-42. Review.
Latella L, Lukas J, Simone C, Puri PL, Bartek J. Differentiation-induced radioresistance in muscle cells. Mol Cell Biol. 2004 Jul;24(14):6350-61.
Zhu Y, Alvarez C, Doll R, Kurata H, Schebye XM, Parry D, Lees E. Intra-S-phase checkpoint activation by direct CDK2 inhibition. Mol Cell Biol. 2004 Jul;24(14):6268-77.
Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson SP, Bartek J, Lukas J. Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J. 2004 Jul 7;23(13):2674-83. Epub 2004 Jun 17.
Dynlacht JR, Xu M, Pandita RK, Wetzel EA, Roti Roti JL. Effects of heat shock on the Mre11/Rad50/Nbs1 complex in irradiated or unirradiated cells. Int J Hyperthermia. 2004 Mar;20(2):144-56.
Rogoff HA, Kowalik TF. Life, Death and E2F: Linking Proliferation Control and DNA Damage Signaling via E2F1. Cell Cycle. 2004 Jul 14 [Epub ahead of print]
JUNE 2004 Scientific papers Steffen J, Varon R, Mosor M, Maneva G, Maurer M, Stumm M, Nowakowska D, Rubach M, Kosakowska E, Ruka W, Nowecki Z, Rutkowski P, Demkow T, Sadowska M, Bidzinski M, Gawrychowski K, Sperling K. Increased cancer risk of heterozygotes with NBS1 germline mutations in poland. Int J Cancer. 2004 Aug 10;111(1):67-71.
Robison JG, Elliott J, Dixon K, Oakley GG. Replication protein A and the Mre11/Rad50/Nbs1 complex Co-localize and interact at sites of stalled replication forks. J Biol Chem. 2004 Jun 4 [Epub ahead of print]
Wu X, Avni D, Chiba T, Yan F, Zhao Q, Lin Y, Heng H, Livingston D. SV40 T antigen interacts with Nbs1 to disrupt DNA replication control. Genes Dev. 2004 Jun 1;18(11):1305-16.
Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 2004 Jun 2 [Epub ahead of print]
Sasaki MS, Takata M, Sonoda E, Tachibana A, Takeda S. Recombination repair pathway in the maintenance of chromosomal integrity against DNA interstrand crosslinks. Cytogenet Genome Res. 2004;104(1-4):28-34.
Pichierri P, Averbeck D, Rosselli F. DNA cross-link-dependent RAD50/MRE11/NBS1 subnuclear assembly requires the Fanconi anemia C protein. Hum Mol Genet. 2004 Jun 15;13(12):1289.
Powers JT, Hong S, Mayhew CN, Rogers PM, Knudsen ES, Johnson DG. E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis. Mol Cancer Res. 2004 Apr;2(4):203-14.
Costanzo V, Paull T, Gottesman M, Gautier J. Mre11 assembles linear DNA fragments into DNA damage signaling complexes. PLoS Biol. 2004 May;2(5):E110. Epub 2004 May 11.
Gorski MM, Romeijn RJ, Eeken JC, De Jong AW, Van Veen BL, Szuhai K, Mullenders LH, Ferro W, Pastink A. Disruption of Drosophila Rad50 causes pupal lethality, the accumulation of DNA double-strand breaks and the induction of apoptosis in third instar larvae. DNA Repair (Amst). 2004 Jun 3;3(6):603-15.
MAY 2004 Scientific papers Kawabe T. G2 checkpoint abrogators as anticancer drugs. Mol Cancer Ther. 2004 Apr;3(4):513-9.
Wilkinson DE, Weller SK. Recruitment of Cellular Recombination and Repair Proteins to Sites of Herpes Simplex Virus Type 1 DNA Replication Is Dependent on the Composition of Viral Proteins within Prereplicative Sites and Correlates with the Induction of the DNA Damage Response. J Virol. 2004 May;78(9):4783-96.
Lee JH, Paull TT. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science. 2004 Apr 2;304(5667):93-6.
Giannini G, Rinaldi C, Ristori E, Ambrosini MI, Cerignoli F, Viel A, Bidoli E, Berni S, D'Amati G, Scambia G, Frati L, Screpanti I, Gulino A. Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability. Oncogene. 2004 Apr 8;23(15):2640-7.
Horejsi Z, Falck J, Bakkenist CJ, Kastan MB, Lukas J, Bartek J. Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation. Oncogene. 2004 Apr 15;23(17):3122-7.
Arthur LM, Gustausson K, Hopfner KP, Carson CT, Stracker TH, Karcher A, Felton D, Weitzman MD, Tainer J, Carney JP. Structural and functional analysis of Mre11-3. Nucleic Acids Res. 2004 Mar 26;32(6):1886-93. Print 2004.
Seno JD, Dynlacht JR. Intracellular redistribution and modification of proteins of the Mre11/Rad50/Nbs1 DNA repair complex following irradiation and heat-shock. J Cell Physiol. 2004 May;199(2):157-70.
Petrini JH, Theunissen JW. Double Strand Break Metabolism and Cancer Susceptibility: Lessons from the Mre11 Complex. Cell Cycle. 2004 May [Epub ahead of print]
APRIL 2004 Scientific papers Seeman P, Gebertova K, Paderova K, Sperling K, Seemanova E. Nijmegen breakage syndrome in 13% of age-matched Czech children with primary microcephaly. Pediatr Neurol. 2004 Mar;30(3):195-200.
Cheng WH, Von Kobbe C, Opresko PL, Arthur LM, Komatsu K, Seidman MM, Carney JP, Bohr VA. Linkage between werner syndrome protein and the Mre11 complex via Nbs1. J Biol Chem. 2004 Mar 16 [Epub ahead of print]
Rogoff HA, Pickering MT, Frame FM, Debatis ME, Sanchez Y, Jones S, Kowalik TF. Apoptosis associated with deregulated E2F activity is dependent on E2F1 and Atm/Nbs1/Chk2. Mol Cell Biol. 2004 Apr;24(7):2968-77.
Forsti A, Angelini S, Festa F, Sanyal S, Zhang Z, Grzybowska E, Pamula J, Pekala W, Zientek H, Hemminki K, Kumar R. Single nucleotide polymorphisms in breast cancer. Oncol Rep. 2004 Apr;11(4):917-22.
MARCH 2004 Scientific papers Kuimov AN. Polypeptide components of telomere nucleoprotein complex. Biochemistry (Mosc). 2004 Feb;69(2):117-29.
Pichierri P, Rosselli F. The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. EMBO J. 2004 Feb 26 [Epub ahead of print]
Takakuwa T, Luo WJ, Francisca Ham M, Aozasa K. A 50-bp insertion from intron 2 between exons 2 and 3 of NBS1 may be a spliced variant. Genes Chromosomes Cancer. 2004 Apr;39(4):341-342.
Muschke P, Gola H, Varon R, Ropke A, Zumkeller W, Wieacker P, Stumm M. Retrospective diagnosis and subsequent prenatal diagnosis of Nijmegen breakage syndrome. Prenat Diagn. 2004 Feb;24(2):111-3.
Cybulski C, Gorski B, Debniak T, Gliniewicz B, Mierzejewski M, Masojc B, Jakubowska A, Matyjasik J, Zlowocka E, Sikorski A, Narod SA, Lubinski J. NBS1 is a prostate cancer susceptibility gene. Cancer Res. 2004 Feb 15;64(4):1215-9.
Borde V, Lin W, Novikov E, Petrini JH, Lichten M, Nicolas A. Association of Mre11p with double-strand break sites during yeast meiosis. Mol Cell. 2004 Feb 13;13(3):389-401.
FEBRUARY 2004 Scientific papers Lahdesmaki A, Taylor AM, Chrzanowska KH, Pan-Hammarstrom Q. Delineation of the role of the Mre11 complex in class switch recombination. J Biol Chem. 2004 Jan 26 [Epub ahead of print]
Jang ER, Lee JH, Lim DS, Lee JS. Analysis of ataxia-telangiectasia mutated (ATM)- and Nijmegen breakage syndrome (NBS)-regulated gene expression patterns. J Cancer Res Clin Oncol. 2004 Jan 23 [Epub ahead of print]
Eastman A. Cell cycle checkpoints and their impact on anticancer therapeutic strategies. J Cell Biochem. 2004 Feb 1; 91(2): 223-31.
Varon R, Schoch C, Reis A, Hiddemann WC, Sperling K, Schnittger S. Mutation analysis of the Nijmegen breakage syndrome gene (NBS1) in nineteen patients with acute myeloid leukemia with complex karyotypes. Leuk Lymphoma. 2003 Nov; 44(11): 1931-4.
JANUARY 2004 Scientific papers Rosselli F, Briot D, Pichierri P. The Fanconi anemia pathway and the DNA interstrand cross-links repair. Biochimie. 2003 Nov; 85(11): 1175-84.
Bassing CH, Alt FW. H2AX May Function as an Anchor to Hold Broken Chromosomal DNA Ends in Close Proximity. Cell Cycle. 2004 Mar-Apr;3(2):149-53.
Bai Y, Murnane JP. Telomere Instability in a Human Tumor Cell Line Expressing NBS1 With Mutations at Sites Phosphorylated by ATM. Mol Cancer Res. 2003 Dec;1(14):1058-69.
Zhang J, Willers H, Feng Z, Ghosh JC, Kim S, Weaver DT, Chung JH, Powell SN, Xia F. Chk2 Phosphorylation of BRCA1 Regulates DNA Double-Strand Break Repair. Mol Cell Biol. 2004 Jan 15;24(2):708-718.
Moncalian G, Lengsfeld B, Bhaskara V, Hopfner KP, Karcher A, Alden E, Tainer JA, Paull TT. The rad50 signature motif: essential to ATP binding and biological function. J Mol Biol. 2004 Jan 23;335(4):937-51.
Mochan TA, Venere M, DiTullio RA Jr, Halazonetis TD. 53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage. Cancer Res. 2003 Dec 15;63(24):8586-91.
Sanyal S, Festa F, Sakano S, Zhang Z, Steineck G, Norming U, Wijkstrom H, Larsson P, Kumar R, Hemminki K. Polymorphisms in DNA repair and metabolic genes in bladder cancer. Carcinogenesis. 2003 Dec 19 [Epub ahead of print]
DECEMBER 2003 Scientific papers Slijepcevic P. Is There a Link between Telomere Maintenance and Radiosensitivity? Radiat Res. 2004 Jan;161(1):82-6.
Niehues T, Schellong G, Dorffel W, Bucsky P, Mann G, Korholz D, Gobel U. Immunodeficiency and Hodgkin's Disease: Treatment and Outcome in the DAL HD78 - 90 and GPOH HD95 Studies. Klin Padiatr. 2003 Nov-Dec;215(6):315-20.
Carson CT, Schwartz RA, Stracker TH, Lilley CE, Lee DV, Weitzman MD. The Mre11 complex is required for ATM activation and the G(2)/M checkpoint. EMBO J. 2003 Dec 15;22(24):6610-6620.
Hammond EM, Green SL, Giaccia AJ. Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Mutat Res. 2003 Nov 27;532(1-2):205-213.
MichaLkiewicz J, Barth C, Chrzanowska K, Gregorek H, Syczewska M, Weemaes CM, Madalinski K, Stachowski J; D. DZIERZANOWSKA. Abnormalities in the T and NK lymphocyte phenotype in patients with Nijmegen breakage syndrome. Clin Exp Immunol. 2003 Dec;134(3):482-490.
NOVEMBER 2003 Scientific papers Fagagna Fd F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T, Saretzki G, Carter NP, Jackson SP. A DNA damage checkpoint response in telomere-initiated senescence. Nature. 2003 Nov 5 [Epub ahead of print]
Digweed M. Response to environmental carcinogens in DNA-repair-deficient disorders. Toxicology. 2003 Nov 15;193(1-2):111-24.
OCTOBER 2003 Scientific papers Yuan SS, Yang YK, Chen HW, Chung YF, Chang HL, Su JH. Neocarzinostatin-induced Rad51 nuclear focus formation is cell cycle regulated and aberrant in AT cells. Toxicol Appl Pharmacol. 2003 Nov 1;192(3):231-6.
Taylor GM, O'Brien HP, Greaves MF, Ravetto PF, Eden OB. Correspondence re: R. Varon et al., Mutations in the Nijmegen breakage syndrome gene (NBS1) in childhood acute lymphoblastic leukemia. Cancer Res., 61: 3570-3572, 2001. Cancer Res. 2003 Oct 1;63(19):6563-4.
Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 2003 Oct 15;22(20):5612-5621.
Xu X, Stern DF. NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA checkpoint signaling and repair factors. FASEB J. 2003 Oct;17(13):1842-8.
Davalos AR, Campisi J. Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J Cell Biol. 2003 Sep 29;162(7):1197-209.
Kilzer JM, Stracker T, Beitzel B, Meek K, Weitzman M, Bushman FD. Roles of host cell factors in circularization of retroviral dna. Virology. 2003 Sep 15;314(1):460-7.
Angele S, Treilleux I, Bremond A, Taniere P, Hall J. Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas. Histopathology. 2003 Oct;43(4):347-53.
SEPTEMBER 2003 VI CONGRESSO S.I.G.U. VERONA 24-27 Settembre 2003 Palazzo della Gran Guardia Posters and Oral Presentations: Comet Assay nello studio della radiosensibilità in pazienti con Atassia Telangiectasia (AT), Atassia Telangiectasia Variante (ATLD) e Nijmegen Brekage Sindrome (NBS). M. Piane, A. Masci, I. De Santis, C. Savio, E. Genevois, P. Lulli, L. Chessa. Distribuzione degli istoni H2AX-fosforilato e H3-acetilato dopo trattamento con bleomicina in linfociti T di pazienti con Atassia Teleangiectasia e Sindrome di Nijmegen. V. Turinetto, D. Giachino, E. Lantelme, P. Porcedda, S. Regazzoni, V. Monafo, K. Chrzanowska, M. De Marchi, C. Giachino. La sindrome di Nijmegen in Italia. E. Spadoni, A. Di Masi, A. Sgura, A. Antoccia, V. Pecile, A. Guala, G.L. Marseglia, C. Danesino, C. Tanzarella, P. Maraschio.
SEPTEMBER 2003 Scientific papers Lammens M, Hiel JA, Gabreels FJ, Van Engelen BG, Van Den Heuvel LP, Weemaes CM. Nijmegen breakage syndrome: a neuropathological study. Neuropediatrics. 2003 Aug;34(4):189-93.
Lee JH, Ghirlando R, Bhaskara V, Hoffmeyer MR, Gu J, Paull TT. Regulation of Mre11/Rad50 by Nbs1: effects on nucleotide-dependent DNA binding and association with ATLD mutant complexes. J Biol Chem. 2003 Sep 8 [Epub ahead of print]
Habraken Y, Jolois O, Piette J. Differential involvement of the hMRE11/hRAD50/NBS1 complex, BRCA1 and MLH1 in NF-kappaB activation by camptothecin and X-ray. Oncogene. 2003 Sep 4;22(38):6090-9.
Krause DR, Jonnalagadda JC, Gatei MH, Sillje HH, Zhou BB, Nigg EA, Khanna K. Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. Oncogene. 2003 Sep 4;22(38):5927-37.
Van Den Bosch M, Bree RT, Lowndes NF. The MRN complex: coordinating and mediating the response to broken chromosomes. EMBO Rep. 2003 Sep;4(9):844-9.
AUGUST 2003 Scientific papers ERRATUM in: Int J Cancer. 2003 Oct 10;106(6):984. TO Gorski B, Debniak T, Masojc B, Mierzejewski M, Medrek K, Cybulski C, Jakubowska A, Kurzawski G, Chosia M, Scott R, Lubinski J. Germline 657del5 mutation in the NBS1 gene in breast cancer patients. Int J Cancer. 2003 Sep 1;106(3):379-81.
Udayakumar D, Bladen CL, Hudson FZ, Dynan WS. Distinct pathways of nonhomologous end joining that are differentially regulated by DNA-dependent protein kinase mediated phosphorylation. J Biol Chem. 2003 Aug 12 [Epub ahead of print]
Medina PP, Ahrendt SA, Pollan M, Fernandez P, Sidransky D, Sanchez-Cespedes M. Screening of Homologous Recombination Gene Polymorphisms in Lung Cancer Patients Reveals an Association of the NBS1-185Gln Variant and p53 Gene Mutations. Cancer Epidemiol Biomarkers Prev. 2003 Aug;12(8):699-704.
Debniak T, Gorski B, Cybulski C, Jakubowska A, Kurzawski G, Lener M, Mierzejewski M, Masojc B, Medrek K, Kladny J, Zaluga E, Maleszka R, Chosia M, Lubinski J. Germline 657del5 mutation in the NBS1 gene in patients with malignant melanoma of the skin. Melanoma Res. 2003 Aug;13(4):365-370.
Lee JH, Xu B, Lee CH, Ahn JY, Song MS, Lee H, Canman CE, Lee JS, Kastan MB, Lim DS. Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Mol Cancer Res. 2003 Jul;1(9):674-81.
JULY 2003 Scientific papers Michallet AS, Lesca G, Radford-Weiss I, Delarue R, Varet B, Buzyn A. T-cell prolymphocytic leukemia with autoimmune manifestations in Nijmegen breakage syndrome. Ann Hematol. 2003 Jul 3 [Epub ahead of print]
Gorski B, Debniak T, Masojc B, Mierzejewski M, Medrek K, Cybulski C, Jakubowska A, Kurzawski G, Chosia M, Scott R, Lubinski J. Germline 657del5 mutation in the NBS1 gene in breast cancer patients. Int J Cancer. 2003 Sep 1;106(3):379-81.
Resnick IB, Kondratenko I, Pashanov E, Maschan AA, Karachunsky A, Togoev O, Timakov A, Polyakov A, Tverskaya S, Evgrafov O, Roumiantsev AG. 657del5 mutation in the gene for Nijmegen breakage syndrome (NBS1) in a cohort of Russian children with lymphoid tissue malignancies and controls. Am J Med Genet. 2003 Jul 15;120A(2):174-9.
Kool J, Hamdi M, Cornelissen-Steijger P, Van Der Eb AJ, Terleth C, Van Dam H. Induction of ATF3 by ionizing radiation is mediated via a signaling pathway that includes ATM, Nibrin1, stress-induced MAPkinases and ATF-2. Oncogene. 2003 Jul 3;22(27):4235-42.
JUNE 2003 Scientific papers Siwicki JK, Degerman S, Chrzanowska KH, Roos G. Telomere maintenance and cell cycle regulation in spontaneously immortalized T-cell lines from Nijmegen breakage syndrome patients. Exp Cell Res. 2003 Jul 1;287(1):178-89.
Soucek P, Gut I, Trneny M, Skovlund E, Grenaker Alnaes G, Kristensen T, Borresen-Dale AL, Kristensen VN. Multiplex single-tube screening for mutations in the Nijmegen Breakage Syndrome (NBS1) gene in Hodgkin's and non-Hodgkin's lymphoma patients of Slavic origin. Eur J Hum Genet. 2003 May;11(5):416-9.
Wu G, Jiang X, Lee WH, Chen PL. Assembly of Functional ALT-associated Promyelocytic Leukemia Bodies Requires Nijmegen Breakage Syndrome 1. Cancer Res. 2003 May 15;63(10):2589-95.
MAY 2003 Biological Basis of Sensitivity to Ionizing Radiation International Workshop, DKFZ, Heidelberg, May 9-10, 2003 Workshop homepage: www.dkfz.de/tox/bbsir2003.html
MAY 2003 Scientific papers Cerosaletti KM, Concannon P. The Nibrin FHA and BRCT domains are both required for nuclear focus formation and phosphorylation. J Biol Chem. 2003 Apr 4 [epub ahead of print] Free on-line at: www.jbc.org
Tanzanella C, Antoccia A, Spadoni E, di Masi A, Pecile V, Demori E, Varon R, Marseglia GL, Tiepolo L, Maraschio P. Chromosome instability and nibrin protein variants in NBS heterozygotes. Eur J Hum Genet. 2003 Apr;11(4):297-303.
Maraschio P, Spadoni E, Tanzarella C, Antoccia A, Di Masi A, Maghnie M, Varon R, Demuth I, Tiepolo L, Danesino C. Genetic heterogeneity for a Nijmegen breakage-like syndrome. Clin Genet. 2003 Apr;63(4):283-290.